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D ASPARTIC ACID Benefits, Uses, Side Effects, Precautions 2023


D ASPARTIC ACID Benefits, Uses, Side Effects, Precautions 2023

Aspartic acid increases the absorption, distribution, and use of minerals such as calcium, magnesium, zinc, and potassium. In addition, it protects the cardiovascular system and participates in a multitude of metabolic and cellular functions.

Aspartic acid, or its ionized form aspartate, is a nonessential amino acid that participates in protein synthesis. It acts as a neurotransmitter and, like the other amino acids, it can be found in its two forms (isomers): D and L. It is also called asparagine acid. Form D occurs naturally in the body of animals and is synthesized from dietary amino acid L-aspartic.

Aspartic acid is important in the production and secretion of hormones such as luteinizing hormone (LH) and growth hormone (GH). Luteinizing hormone is the chemical messenger that travels from the pituitary to the testes to stimulate testosterone production. D-aspartic acid has also been shown to have a stimulating effect on the production of testosterone in the testes, increasing testosterone levels naturally and safely by up to 42%, improving the quality of sexual life in men.

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D ASPARTIC ACID Benefits, Uses, Side Effects, Precautions 2023

Aspartic acid intervenes during liver detoxification and is important for its proper functioning thanks to the fact that it forms molecules capable of absorbing toxins from the bloodstream. This is the case of ammonia, which is eliminated through the urea cycle. Aspartic acid, in turn, has the ability to protect against the damaging effects of radiation.

This amino acid participates in functions of the central nervous system, participating in brain connections and learning. It also helps maintain emotional balance and intervenes in the proper development of the senses of hearing and touch.

Aspartic acid increases the absorption, circulation, and utilization of minerals such as calcium, magnesium, zinc, and potassium. In addition, it protects the cardiovascular system and participates in a multitude of metabolic and cellular functions.

d aspartic acid side effects

They found no safety concerns and concluded that this supplement is safe to consume for at least 90 days. On the other hand, another study found that two of 10 men taking D-aspartic acid reported irritability, headaches, and nervousness. However, these effects were also reported by one man in the placebo group ( 5 ).

Is There a Recommended Dosage?

Most studies examining the effects of D-aspartic acid on testosterone have used doses of 2.6–3 grams per day (5Trusted Source, 6Trusted Source, 7, 8, 9Trusted Source).

As discussed earlier, research has shown mixed results for its effects on testosterone.

Doses of around 3 grams per day have been shown to be effective in some young and middle-aged men who were likely physically inactive (6Trusted Source, 7, 8).

However, this same dose has not been shown to be effective in active young men (5Trusted Source, 9Trusted Source).

Higher doses of 6 grams per day have been used in two studies without promising results.

While one short study showed a decrease in testosterone with this dose, the longer study showed no changes (9Trusted Source, 10Trusted Source).

The study that reported beneficial effects of D-aspartic acid on sperm quantity and quality used a dose of 2.6 grams per day for 90 days (8).

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In sports, it intervenes by promoting muscle development, reducing fatigue, participating in gluconeogenesis, and the formation of glutamic acid or glutamate.

Some of the foods with the highest content of aspartic acid:

  • Animal origin: meat, chicken, fish, eggs, and dairy.
  • Plant origin: legumes, sugar cane, molasses, nuts, cereals, seeds, asparagus, spinach, pumpkin, potatoes, carrots, aubergines, peppers, celery, lettuce, chicory, garlic, onions, and fruits.
  • Aspartic acid combines with the amino acid phenylalanine to form the sweetener aspartame.


Its supplementation seeks to prevent deficiencies and prevent any of the functions from being diminished. It is used especially in cases of neuritis, fatigue, weakness, and depression.

Its supplementation in sports seeks to improve the secretion of anabolic hormones to stimulate protein synthesis and reduce fatigue to improve sports performance.

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The amounts of aspartic acid used are about 500 mg/day. Aspartic acid can be taken up to three times a day with water or juice. When used to increase athletic performance, it is thought to be best consumed in an aspartic acid supplement, without combining it in the same intake with other proteins.

To improve athletic capacity in sports competitions, the recommendations are increased to about 4,000 and 8,000 mg taken 24 hours before the sporting event. However long-term supplementation in these amounts is not recommended.

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The consumption of aspartic acid does not present adverse effects in healthy people. However, it is not recommended to ingest large amounts of these amino acids to people with liver or kidney problems, pregnant women, if they suffer from epilepsy, ischemic brain lesions, or Alzheimer’s.

What does D aspartic acid do for you?

D-Aspartic acid is a natural amino acid that can boost low testosterone levels. Research suggests that it works mainly by increasing levels of follicle-stimulating hormone and luteinizing hormone, the latter of which stimulates Leydig cells in the testes to produce more testosterone ( 3 ).

Should I take D aspartic acid?

D-aspartic acid is currently recommended as a viable product to significantly raise testosterone, however research in humans only supports this recommendation in untrained men with below-average testosterone levels.

Does DAA increase testosterone?

Research on d-aspartic acid (DAA) has demonstrated increases in total testosterone levels in untrained men, however, research in resistance-trained men demonstrated no changes and reductions in testosterone levels

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Does D aspartic acid increase estrogen?

The studies confirmed that DAA is capable of increasing testosterone release and subsequent estrogen production by increasing aromatase activity.

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